(M88) Paget disease of bone [osteitis deformans]

More details coming soon

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26 934 in individuals diagnosis paget disease of bone [osteitis deformans] confirmed
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5 672 deaths with diagnosis paget disease of bone [osteitis deformans]
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21% mortality rate associated with the disease paget disease of bone [osteitis deformans]

Diagnosis paget disease of bone [osteitis deformans] is diagnosed Women are 31.03% more likely than Men

9 288

Men receive the diagnosis paget disease of bone [osteitis deformans]

2 244 (24.2 %)

Died from this diagnosis.

100
95
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60
55
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17 646

Women receive the diagnosis paget disease of bone [osteitis deformans]

3 428 (19.4 %)

Died from this diagnosis.

Risk Group for the Disease paget disease of bone [osteitis deformans] - Men aged 55-59 and Women aged 50-54

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In Men diagnosis is most often set at age 0-14, 25-29, 40-89
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Less common in men the disease occurs at Age 0-1, 15-24, 30-39, 90-95+Less common in women the disease occurs at Age 0-19, 40-44, 90-95+
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In Women diagnosis is most often set at age 20-39, 45-89

Disease Features paget disease of bone [osteitis deformans]

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Non-contagious
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Moderate individual risk, low public risk

Paget disease of bone [osteitis deformans] - what does this mean

Paget disease of bone (osteitis deformans) is a chronic disorder of the bone that is caused by an abnormal increase in the rate of bone remodeling. this leads to destruction of normal bone and its replacement with an abnormally formed, weakened, and enlarged bone. the abnormal bone is prone to fractures and can cause pain, deformity, and impaired function.

What happens during the disease - paget disease of bone [osteitis deformans]

Paget disease of bone (osteitis deformans) is a chronic bone disorder characterized by increased bone turnover. it is caused by a genetic mutation in the gene that regulates osteoclast activity, leading to an imbalance between the formation and resorption of bone. this results in an increase in the rate of bone turnover, leading to abnormal bone growth and remodeling, which can cause deformity and pain.

Clinical Pattern

More details coming soon

How does a doctor diagnose

  • X-ray imaging
  • Bone biopsy
  • CT scan
  • Bone scan
  • Blood tests
  • Urine tests

Treatment and Medical Assistance

Main Goal: To reduce pain, improve mobility, and slow the progression of Paget disease of bone.
  • Medication: Bisphosphonates, Calcitonin, Corticosteroids, Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Surgery: Joint replacement, Osteotomy, Core decompression
  • Physical Therapy: Exercises, Joint mobilization, Heat and cold therapy
  • Nutritional Support: Calcium, Vitamin D, Magnesium, Vitamin K
  • Other Treatments: Radiotherapy, Stem cell therapy
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9 Days of Hospitalization Required
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Average Time for Outpatient Care Not Established

Paget disease of bone [osteitis deformans] - Prevention

Paget disease of bone can be prevented by maintaining a healthy lifestyle, including regular exercise, a balanced diet, and avoiding smoking and excessive alcohol consumption. additionally, adequate calcium and vitamin d intake is important to ensure proper bone health. regular check-ups with a doctor and monitoring of bone health is also recommended.

Main symptoms of the disease paget disease of bone [osteitis deformans]

Joint pain

(Arthritis, Rheumatism, Aches, Stiffness, Inflammation, Tenderness, Soreness, Swollen joints, Stabbing pain, Throbbing pain, Sharp pain, Dull ache)

Joint pain is a common symptom that can range from mild to severe. It is often caused by inflammation or injury to the joints, muscles, or tendons. It can be localized to one joint or affect multiple joints. It can be acute, lasting only a few days or chronic, lasting weeks or months. It may manifes...

Age: any ageAccociated with 130 diseases

Pain in the bones

(Aches, Agony, Distress, Misery, Soreness, Suffering, Torture, Torment, Agonizing, Tenderness, Throbbing, Sharpness, Stabbing, Pricking, Twinge, Throb, Pang)

Bone pain is a dull, deep, aching sensation that is felt in the bones or joints. It can range from mild to severe, and can be a constant or an intermittent ache. It can develop suddenly or gradually, and can be localized to one area or widespread throughout the body. It can manifest as a sharp, stab...

Age: any ageAccociated with 42 diseases

Decreased visual acuity

(Reduced eyesight, Blurred vision, Fuzzy vision, Hazy vision, Dim vision, Poor vision, Clouded vision, Blind spots, Poor focusing, Decreased sharpness, Loss of visual clarity)

Decreased visual acuity is a symptom of vision loss or impairment. It is characterized by a decrease in the ability to see clearly and distinguish objects at a distance. It can develop gradually over time or be sudden, and may be accompanied by other symptoms such as blurriness, double vision, or se...

Age: any ageAccociated with 40 diseases

Bone deformity

(Skeletal abnormality, Bone malformation, Skeletal malformation, Bone abnormality, Skeletal disorder, Bone disorder, Bone deformity, Skeletal deformity, Bone misalignment, Skeletal misalignment)

Bone deformity is a condition in which the shape of the bone is altered due to disease or injury. It can be caused by a number of factors, including genetic abnormalities, trauma, infection, or tumors. Symptoms of bone deformity can include pain, swelling, limited range of motion, and deformity of t...

Age: any ageAccociated with 25 diseases

Hearing loss

(Auditory impairment, Deafness, Hearing impairment, Hearing reduction, Partial deafness, Sensorineural hearing loss, Presbycusis)

Hearing loss is a decrease in the ability to hear sound. It can be temporary or permanent and can range from mild to severe. Symptoms may include ringing in the ears, difficulty understanding speech, and difficulty hearing high-pitched sounds. Hearing loss can develop gradually over time, or it can ...

Age: any ageAccociated with 37 diseases

Specified forms of the disease

(M88.0) Paget disease of skull
(M88.8) Paget disease of other bones
(M88.9) Paget disease of bone, unspecified